1-Iodopropane → HCID 19354052, compound

HRID 1655054Notes

Reaction equation

HRID 1655054 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH:9]=[CH:10][NH:11]2)=[CH:7][CH:6]=1)=[O:4].[CH2:14](I)[CH2:15][CH3:16]>>[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH:9]=[CH:10][N:11]2[CH2:14][CH2:15][CH3:16])=[CH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 639844Methyl indole-6-carboxylate

Product 1

HCID 19354052HCID 19354052, compound

Procedure

This compound was prepared from methyl-6-indolecarboxylate and propyliodide by the method described in Example 10, part i. The reaction mixture was worked up by removal of the dimethylformamide in vacuo and the residue partitioned between diethyl ether and water. The organic phase was further washed with water and brine, dried and evaporated. The resulting oil was purified by chromatography on flash silica eluting with petroleum spirit 40°-60° C.-diethyl ether (9:1) to give the product as a colourless oil.

Workup

  1. customThe reaction mixture was worked up by removal of the dimethylformamide in vacuo
  2. customthe residue partitioned between diethyl ether and water
  3. washThe organic phase was further washed with water and brine
  4. customdried
  5. customevaporated
  6. customThe resulting oil was purified by chromatography on flash silica eluting with petroleum spirit 40°-60° C.-diethyl ether (9:1)

Sources & evidence

ORD record
ord-6550e29677f44fb99986a2558d3382dd
Source dataset
uspto-grants-1995_04
Patent number
US05410061

Reaction notes

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