反应详情

A mixture of 2-n-butyl-4-(2-aminoethyl)-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole hydrochloride (0.278 g), ethyl glyoxylate (0.179 g) and ethanol (5 ml) is refluxed for three days. To the mixture is added chloroform, and the mixture is washed, dried and evaporated to remove the solvent. The solvent is purified by silica gel column chromatography (solvent; chloroform/methanol=10.1) to give ethyl 2-n-butyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine-4-carboxylate (0.136 g) as a foam.

1. temperatureis refluxed for three days
2. washthe mixture is washed
3. customdried
4. customevaporated
5. customto remove the solvent
6. customThe solvent is purified by silica gel column chromatography (solvent; chloroform/methanol=10.1)