Sodium Methoxide → HCID 15114060, compound

HRID 1655141Notes

Reaction equation

HRID 1655141 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([NH2:16])=[NH:15])=[CH:12][CH:11]=2)[CH:6]=[CH:7][C:8]=1[F:9].C[O-].[Na+]>CO>[CH2:4]([C:5]1[CH:6]=[N:15][C:14]([C:13]2[CH:17]=[CH:18][C:10]([C:5]3[CH:6]=[CH:7][C:8]([F:9])=[C:3]([F:2])[CH:4]=3)=[CH:11][CH:12]=2)=[N:16][CH:10]=1)[CH2:3][CH3:8]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 19790528HCID 19790528, compound

Product 1

HCID 15114060HCID 15114060, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.01 mol of 4-(3,4-difluorophenyl)benzamidine hydrochloride and 0.01 mol of α-propyl-β-dimethylaminoacrolein are introduced into a solution of sodium methylate and methanol, and the mixture is refluxed for 5 hours. The methanol is evaporated off, the residue is taken up in toluene, and the solution is subjected to customary aqueous work-up, to give 5-n-propyl-2-[4-(3,4-difluorophenyl)phenyl]pyrimidine.

Workup

  1. temperaturethe mixture is refluxed for 5 hours
  2. customThe methanol is evaporated off

Sources & evidence

ORD record
ord-989215136a5b459592dba39aade34f04
Source dataset
uspto-grants-1993_10
Patent number
US05250220

Reaction notes

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