2-Amino-5-methylpyridine → HCID 19790736, compound

HRID 1655163Notes

Reaction equation

HRID 1655163 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.[Cl:9][C:10]1[S:11][C:12]([CH2:15]Cl)=[CH:13][CH:14]=1>C(#N)C>[ClH:9].[Cl:9][C:10]1[S:11][C:12]([CH2:15][N:3]2[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]2=[NH:1])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 153482-Amino-5-methylpyridineHCID 5830792-Chloro-5-(chloromethyl)thiophene

Product 1

HCID 19790736HCID 19790736, compoundYield 38.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
60 °C

Procedure

3.2 g (0.03 mol) of 2-amino-5-methylpyridine are dissolved in 100 ml of acetonitrile, and 5 g (0.03 mol) of 2-chloro-5-chloromethylthiophene are added. The mixture is stirred for 8 hours at 60° C. and for 18 hours at room temperature. The solid which has formed is filtered off with suction and dried. 1.6 g (20% of theory) of N-(5-chlorothien-2-yl-methyl)-5-methyl-2-iminopyridine hydrochloride of melting point 208° C. are obtained.

Workup

  1. customThe solid which has formed
  2. filtrationis filtered off with suction
  3. customdried

Sources & evidence

ORD record
ord-2de94b2cb5f747548e06f3d55357d99c
Source dataset
uspto-grants-1993_10
Patent number
US05250498

Reaction notes

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