Hydrochloric Acid → HCID 13823606, compound

HRID 1655185Notes

Reaction equation

HRID 1655185 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([C:12]2[C:17]([Cl:18])=[CH:16][C:15]([C:19]([F:22])([F:21])[F:20])=[CH:14][C:13]=2[Cl:23])[C:10]=1[CH3:11])=[O:5])C.[OH-].[Na+].Cl>C(O)C.O>[C:4]([C:6]1[CH:7]=[N:8][N:9]([C:12]2[C:17]([Cl:18])=[CH:16][C:15]([C:19]([F:21])([F:22])[F:20])=[CH:14][C:13]=2[Cl:23])[C:10]=1[CH3:11])([OH:5])=[O:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13823607HCID 13823607, compound

Product 1

HCID 13823606HCID 13823606, compoundYield 93.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

By the method of Example 5, Step B, 137.4 g (0.374 mole) of 4-ethoxycarbonyl-5-methyl-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazole dissolved in 767 mL of ethanol was reacted with 23.6 g (0.59 mole) of sodium hydroxide dissolved in 413 mL of water. After being neutralized with 180 mL of 10% hydrochloric acid, this reaction yielded 119 g of 4-carboxy-5-methyl-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazole. The nmr spectrum of this solid was consistent with the proposed structure.

Sources & evidence

ORD record
ord-31b0f55d79634e3dbbbea95009be15c6
Source dataset
uspto-grants-1993_10
Patent number
US05250504

Reaction notes

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