Malonic Acid → HCID 67858667, compound

HRID 1655189Notes

Reaction equation

HRID 1655189 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:10]2[C:15]([Cl:16])=[CH:14][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:12][C:11]=2[Cl:21])[C:7]=1C=O)#[N:2].[C:22](O)(=O)[CH2:23][C:24]([OH:26])=[O:25]>N1CCCCC1.N1C=CC=CC=1>[C:1]([C:3]1[CH:4]=[N:5][N:6]([C:10]2[C:11]([Cl:21])=[CH:12][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:14][C:15]=2[Cl:16])[C:7]=1[CH:22]=[CH:23][C:24]([OH:26])=[O:25])#[N:2]

Participants

5

Reactant 2

HCID 867Malonic AcidHCID 19020331HCID 19020331, compound

Product 1

HCID 67858667HCID 67858667, compoundYield 56.7%

Reagents, catalysts & solvents 2

HCID 8082PiperidineCatalystHCID 1049PyridineSolvent

Procedure

By the method of Example 5, Step H, 1.5 g (0.0045 mole) of 4-cyano-5-formyl-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazole and 1.0 g (0.0096 mole) of malonic acid were reacted in the presence of 5 mL of pyridine and 10 drops of piperidine, yielding 0.96 g of 3-[4-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-pyrazol-5-yl]acrylic acid. The nmr spectrum of this solid was consistent with the proposed structure.

Sources & evidence

ORD record
ord-4c0b9b898a7d4b4baaec57dd7cd25bd5
Source dataset
uspto-grants-1993_10
Patent number
US05250504

Reaction notes

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