Sodium Hydroxide → HCID 178488128, compound

HRID 1655210Notes

Reaction equation

HRID 1655210 reaction equation
[OH-].[Na+].Cl.[O:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH2:16]Cl)[C:11]=2[Cl:18])[CH2:6][CH2:5]1.[CH3:19][O:20][C:21]1[CH:30]=[CH:29][C:24]2[N:25]=[C:26]([SH:28])[NH:27][C:23]=2[CH:22]=1>>[O:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][S:28][C:26]3[NH:25][C:24]4[CH:29]=[CH:30][C:21]([O:20][CH3:19])=[CH:22][C:23]=4[N:27]=3)[C:11]=2[Cl:18])[CH2:6][CH2:5]1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 197912463-Chloro-2-chloromethyl-4-morpholin-4-yl-pyridinium chlorideHCID 178488032HCID 178488032, compound

Product 1

HCID 178488128HCID 178488128, compound

Procedure

5 N Sodium hydroxide (5.68 ml) was added dropwise to a stirred solution of 4 -morpholino-3 -chloro-2 -chloromethylpyridine hydrochloride (3.66 g) and 5 -methoxy-2 -mercaptobenzimidazole (2.33 g). After standing overnight the solution was evaporated under reduced pressure and the residue triturated with water. The solid thus obtained was recrystallised from ethanol to give 2 -(4 -morpholino-3 -chloro-2 -pyridyl-methylthio)-5 -methoxy-(1H)-benzimidazole, 4.38 g, m.p. 124°-25°.

Workup

  1. customthe solution was evaporated under reduced pressure
  2. customthe residue triturated with water
  3. customThe solid thus obtained
  4. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-cecb825db23a46c4af37c20506c51a37
Source dataset
uspto-grants-1993_10
Patent number
US05250527

Reaction notes

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