HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 2-Methyl-4-(piperidin-1-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Chloro-2-methylpyridine | HCID 581392 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Methyl-4-(piperidin-1-yl)pyridine | HCID 17992216 | — |
Reaction Steps
Piperidine (31.7 ml) and 4 -chloro-2 -picoline (13.65 g) were heated together in a bomb at 170 ° for 4.5 hours. After cooling, the mixture was taken up in water and extracted with ether. After drying (K2CO3) and stripping, the residue was distilled to give 4 -piperidino-2 -picoline, 15.45 g, b.p. 105°-10 ° (0.1 mm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05250527 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-6f57cdeb9a6d4f848a172e397b916673 |
| Source note | uspto-grants-1993_10 |