Piperidine → 2-Methyl-4-(piperidin-1-yl)pyridine

HRID 1655213Notes

Reaction equation

HRID 1655213 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH3:14])[CH:9]=1>O>[N:1]1([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([CH3:14])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 5813924-Chloro-2-methylpyridine

Product 1

HCID 179922162-Methyl-4-(piperidin-1-yl)pyridine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Piperidine (31.7 ml) and 4 -chloro-2 -picoline (13.65 g) were heated together in a bomb at 170 ° for 4.5 hours. After cooling, the mixture was taken up in water and extracted with ether. After drying (K2CO3) and stripping, the residue was distilled to give 4 -piperidino-2 -picoline, 15.45 g, b.p. 105°-10 ° (0.1 mm).

Workup

  1. temperatureAfter cooling
  2. extractionextracted with ether
  3. dry with materialAfter drying (K2CO3)
  4. distillationthe residue was distilled

Sources & evidence

ORD record
ord-6f57cdeb9a6d4f848a172e397b916673
Source dataset
uspto-grants-1993_10
Patent number
US05250527

Reaction notes

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