Morpholine → HCID 19791163, compound

HRID 1655224Notes

Reaction equation

HRID 1655224 reaction equation
[NH:1]1[CH2:6][CH2:5]O[CH2:3][CH2:2]1.Cl[C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10]([CH2:15][OH:16])[CH:9]=1.ClC1C(O)=NC=CC=1Cl>>[N:1]1([C:8]2[C:13]([Br:14])=[CH:12][N:11]=[C:10]([CH2:15][OH:16])[CH:9]=2)[CH2:6][CH2:5][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 19791171(5-Bromo-4-chloropyridin-2-yl)methanolHCID 178517746HCID 178517746, compound

Product 1

HCID 19791163HCID 19791163, compound

Procedure

Substituting pyrrolidine (7.4 ml) for morpholine and 4-chloro-5-bromo-2-hydroxymethylpyridine (4 g) for 3,4-dichloro-2-hydroxypyridine and using corresponding molar proportions of the other reagents in the method of Example 3D gave 4-pyrrolidino-5-bromo-2-hydroxymethylpyridine. 2.28 g, m.p. 108°-10° C., from ether.

Sources & evidence

ORD record
ord-e4777c56e206437f8868292970e2643d
Source dataset
uspto-grants-1993_10
Patent number
US05250527

Reaction notes

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