反应详情

5.5 g (0.02 mol) of 4-chloro-2-(2-pyridyl)-6-(4-fluorophenyl)-pyrimidine are dissolved in 50 ml of dry methanol, 8.6 g of a 22% strength solution of sodium methylate in methanol (corresponds to 0.04 mol) are added, and the mixture is refluxed for 40 hours. After the solvent has been removed, the residue obtained is taken up in ethyl acetate and the mixture is washed twice with water and dried over sodium sulphate. After the solvent has been removed, 4.3 g (77% of theory) of 4-methoxy-2-(2-pyridyl)-6-(4-fluorophenyl)-pyrimidine of melting point 97°-98° C. are obtained.

1. temperaturethe mixture is refluxed for 40 hours
2. customAfter the solvent has been removed
3. customthe residue obtained
4. washthe mixture is washed twice with water
5. dry with materialdried over sodium sulphate
6. customAfter the solvent has been removed