(4-Fluorophenyl)hydrazine → HCID 15646123, compound

HRID 1655272Notes

Reaction equation

HRID 1655272 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]N)=[CH:4][CH:3]=1.[CH2:10]1[CH:17]2[NH:18][CH:12]([CH2:13][C:14]([CH2:16]2)=O)[CH2:11]1>C(O)C>[F:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[NH:8][C:14]1[CH2:13][CH:12]3[NH:18][CH:17]([C:16]2=1)[CH2:10][CH2:11]3

Participants

4

Reactant 2

HCID 69982(4-Fluorophenyl)hydrazineHCID 4344538-Azabicyclo(3.2.1)octan-3-one

Product 1

HCID 15646123HCID 15646123, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared from 4-fluorophenylhydrazine and nortropinone by the procedures described in Example 1, Method A (75% yield) or Method B (60% yield). A hydrogen fumarate hemihydrate was prepared in ethanol, mp 145° C. dec; NMR (DMSO-D6) d 1.71-1.78. (1H, m), 1.95-1.98 (1H, m), 2.19-2.22 (2H, m), 2.79 (1H, d, J=16.8 Hz), 3.36 (1H, dd, J-16.9, 4.4 Hz), 4.33 (1H, bs), 5.00 (1H, d, J=4.2 Hz), 6.43 (2H, s), 6.84-6.91 (1H, m), 7.28=7.36 (2H, m), 11.30 (1H, s). Anal. (C13H13N2F.C4H4O4.0.5H2O).

Sources & evidence

ORD record
ord-cab6c133e0d84eacb32d59ec7ddd5822
Source dataset
uspto-grants-1993_10
Patent number
US05250537

Reaction notes

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