Allyl bromide → HCID 19791572, compound

Temperature

40 °C

29.9 g (1.1 g-atom) of aluminium flakes and 100 mg of mercury(II) chloride are suspended in 300 ml of anhydrous tetrahydrofuran under argon. The mixture is heated to 40° C. and 1-2 ml of 214.0 g (1.77 mol) of allyl bromide in 250 ml of anhydrous tetrahydrofuran are slowly added dropwise. The temperature during this rises to approximately 50° C. The allyl bromide solution is then added dropwise with stirring at such a rate that the temperature of the solution does not exceed 50° C. The solution is subsequently stirred for 1 hour at 60° C., and cooled to -60° C. and 112.4 g (0.765 mol) of 2-methoxypyridine-3-carbaldehyde in 250 ml of anhydrous tetrahydrofuran are added dropwise at this temperature. The mixture is then stirred for 1 hour at 0° C. and for 2 hours at 20° C. Subsequently, 500 ml of saturated ammonium chloride solution are added dropwise with cooling, the mixture is stirred for 0.5 hours, filtered and the filtrate is concentrated in vacuo. The residue is taken up in ethyl acetate, washed with water and dried over sodium sulphate. 136.1 g of a light yellow oil is obtained which is fractionally distilled.

1. customthis rises to approximately 50° C
2. customdoes not exceed 50° C
3. stirringThe solution is subsequently stirred for 1 hour at 60° C.
4. temperaturecooled to -60° C.
5. stirringThe mixture is then stirred for 1 hour at 0° C. and for 2 hours at 20° C
6. temperaturewith cooling
7. stirringthe mixture is stirred for 0.5 hours
8. filtrationfiltered
9. concentrationthe filtrate is concentrated in vacuo
10. washwashed with water
11. dry with materialdried over sodium sulphate

ORD record

ord-137d822f12374dc5b0c9f0cae5d4fe47

Source dataset

uspto-grants-1993_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05250540