Dimethylformamide → HCID 19791571, compound

HRID 1655280Notes

Reaction equation

HRID 1655280 reaction equation
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].[CH3:13][N:14](C)[CH:15]=[O:16]>>[C:1]1(=[O:11])[N:5]([CH2:3][CH:7]2[O:16][C:15]3=[N:14][CH:13]=[CH:1][CH:2]=[C:10]3[CH2:9][CH2:8]2)[C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 24194345Phthalimide potassium salt

Product 1

HCID 19791571HCID 19791571, compound

Procedure

15.0 g (70 mmol) of a mixture of the compounds from Example V and VI (ratio 12:5) are heated at 100° C. with 16.0 g (86 mmol) of potassium phthalimide in 150 ml of dimethylformamide under nitrogen with stirring for 20 hours. Dimethylformamide is then distilled off in vacuo and the residue is partitioned between dichloromethane and water. 24.0 g of crystals having a melting range of 152°-158° C. are obtained.

Workup

  1. distillationDimethylformamide is then distilled off in vacuo
  2. customthe residue is partitioned between dichloromethane and water
  3. customare obtained

Sources & evidence

ORD record
ord-ba324ade2f794186a7027912dc497e7d
Source dataset
uspto-grants-1993_10
Patent number
US05250540

Reaction notes

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