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HRID1655306

反应详情

EQUATION

反应方程式

HRID 1655306 的结构方程式

REACTANTS

反应物

3
结构：N
HCID222

Ammonia gas

H3N

结构：O=Cc1cccc([N+](=O)[O-])c1
HCID7449

3-Nitrobenzaldehyde

C7H5NO3

结构：COC(=O)CC(C)=O
HCID7757

Methyl acetoacetate

C5H8O3

PRODUCTS

生成物

1
结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1
HCID89082

m-Nifedipine

C17H18N2O6

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A mixture of 75.5 g (0.50 mole) of 3-nitrobenzaldehyde, 116 g (1.00 mole) of methyl acetoacetate and 55 ml (1.50 mole) of 28% ammonia in 150 ml of methanol is heated under reflux for 5 hr.

WORKUP

后处理

  1. temperatureis heated
  2. temperatureunder reflux for 5 hr