反应详情

24.0 g (0.15 mole) of 2-formylphenylacetic acid and 0.1 g of p-toluenesulfonic acid in 250 ml of methanol are refluxed for 2 hours. Thereafter, the solution is evaporated down, the residue is taken up in diethyl ether and the solution is washed with dilute HCl. The organic phase is separated off, dried over MgSO4 and evaporated down. The residue is purified by distillation (90° C., 0.4 mbar). 19.3 g (74%) of methyl 2-formylphenylacetate are obtained as a colorless liquid in this manner.

1. customThereafter, the solution is evaporated down
2. washthe solution is washed with dilute HCl
3. customThe organic phase is separated off
4. dry with materialdried over MgSO4
5. customevaporated down
6. distillationThe residue is purified by distillation (90° C., 0.4 mbar)