反应详情

温度

115 °C

A mixture of 2-butyl-1-[(2'-cyanobiphenyl-4-yl)methyl]-7-hydroxymethylbenzimidazole (0.4 g), sodium azide (0.98 g) and ammonium chloride (0.8 g) in DMF (4 ml) was stirred for 4 days at 110-120° C. To the reaction mixture was added water, which was extracted with ethyl acetate. The extract was washed with water and dried. After removal of the solvent, the residue was crystallized from ethyl acetate-methanol to give colorless needles, m.p. 152-153° C.

1. extractionwas extracted with ethyl acetate
2. washThe extract was washed with water
3. customdried
4. customAfter removal of the solvent
5. customthe residue was crystallized from ethyl acetate-methanol
6. customto give colorless needles, m.p. 152-153° C.