反应详情

To a stirred suspension of 2.607 g (8.8 mmol) of the product of Step D and 5.257 g (35.1 mmol) of sodium iodide in 12 mL of acetonitrile was added 2.13 mL (17.5 mmol) of dichlorodimethylsilane via syringe under a nitrogen atmosphere. The reaction mixture which immediately darkened was stirred for 20 min at room temperature, then partitioned between EtOAc and brine. The organic layer was washed with aqueous sodium bicarbonate, 10% aqueous sodium thiosulfate, then dried (MgSO4), filtered and evaporated. The residue was crystallized from EtOAc-hexane to afford 2.214 g (90%) of the title compound as a pale yellow solid.

1. custompartitioned between EtOAc and brine
2. washThe organic layer was washed with aqueous sodium bicarbonate, 10% aqueous sodium thiosulfate
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customevaporated
6. customThe residue was crystallized from EtOAc-hexane