HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butylamine → 2-(Butylamino)pyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | 2-Chloronicotinonitrile | HCID 81079 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(Butylamino)pyridine-3-carbonitrile | HCID 12602979 | — |
Reaction Steps
2-Chloronicotinitrile (1.30 g, 9.60 mmol) was refluxed with 3 mL of n-butylamine and 10 mL of isopropyl alcohol overnight. The solvents were removed in vacuo and the residue obtained chromatographed on silica gel eluting with 2:1 hexane/ethyl acetate to give 1.6 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05250548 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-3654888df14242feb8137a91165712be |
| Source note | uspto-grants-1993_10 |