Butylamine → 2-(Butylamino)pyridine-3-carbonitrile

HRID 1655582Notes

Reaction equation

HRID 1655582 reaction equation
[CH:1]1[CH:6]=[N:5][C:4](Cl)=[C:3]([C:8]#[N:9])[CH:2]=1.[CH2:10]([NH2:14])[CH2:11][CH2:12][CH3:13]>C(O)(C)C>[CH2:10]([NH:14][C:4]1[C:3]([C:8]#[N:9])=[CH:2][CH:1]=[CH:6][N:5]=1)[CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 810792-Chloronicotinonitrile

Product 1

HCID 126029792-(Butylamino)pyridine-3-carbonitrile

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-Chloronicotinitrile (1.30 g, 9.60 mmol) was refluxed with 3 mL of n-butylamine and 10 mL of isopropyl alcohol overnight. The solvents were removed in vacuo and the residue obtained chromatographed on silica gel eluting with 2:1 hexane/ethyl acetate to give 1.6 g of the title compound.

Workup

  1. customThe solvents were removed in vacuo
  2. customthe residue obtained
  3. customchromatographed on silica gel eluting with 2:1 hexane/ethyl acetate

Sources & evidence

ORD record
ord-3654888df14242feb8137a91165712be
Source dataset
uspto-grants-1993_10
Patent number
US05250548

Reaction notes

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