Potassium Hydroxide → HCID 178440043, compound

HRID 1655585Notes

Reaction equation

HRID 1655585 reaction equation
[CH2:1]([C:4]1[C:9]([N:10]([CH2:29][C:30]([O:32]CC)=[O:31])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[NH:28][N:27]=[N:26][N:25]=3)=[CH:14][CH:13]=2)=[CH:8][CH:7]=[CH:6][N:5]=1)[CH2:2][CH3:3].[OH-].[K+]>C(O)C.O>[CH2:1]([C:4]1[C:9]([N:10]([CH2:29][C:30]([OH:32])=[O:31])[CH2:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[NH:28][N:27]=[N:26][N:25]=3)=[CH:16][CH:17]=2)=[CH:8][CH:7]=[CH:6][N:5]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178440044HCID 178440044, compound

Product 1

HCID 178440043HCID 178440043, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

The compound resulting from Example 153E is dissolved in 1 part methylene chloride and 1.5 parts formic acid and stirred at ambient temperature to give 2-propyl-3-{N-ethoxycarbonylmethyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyridine. This ester is hydrolyzed with potassium hydroxide in ethanol/water to give the title compound.

Sources & evidence

ORD record
ord-a33e67f9f67244d1add480a2635b24e4
Source dataset
uspto-grants-1993_10
Patent number
US05250548

Reaction notes

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