Allylamine → HCID 19791950, compound

HRID 1655600Notes

Reaction equation

HRID 1655600 reaction equation
Cl[C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:12]([NH2:15])[CH:13]=[CH2:14]>>[CH2:12]([NH:15][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH:13]=[CH2:14]

Participants

3

Reactant 2

HCID 7853AllylamineHCID 819931Methyl 2-chloronicotinate

Product 1

HCID 19791950HCID 19791950, compoundYield 73.6%

Conditions

Temperature
140 °C

Procedure

Methyl 2-chloropyridine-3-carboxylate (5 g) was reacted neat with allylamine (3.1 g) with heating at 140° C. for 4 hours. The volatiles were removed under reduced pressure and the residue chromatographed on silica gel eluting with ethyl acetate in hexane to afford 4.12 g of the title compound. MS (DCl/NH3) m/e 207 (M+H)+.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customthe residue chromatographed on silica gel eluting with ethyl acetate in hexane

Sources & evidence

ORD record
ord-2e88998d92db44b78485123dba46496a
Source dataset
uspto-grants-1993_10
Patent number
US05250548

Reaction notes

Loading…