Potassium Hydroxide → HCID 11022884, compound

HRID 1655645Notes

Reaction equation

HRID 1655645 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1([C:16]([F:19])([F:18])[F:17])[O:7][C:6]([F:11])([CH2:8][CH2:9]I)[C:5]([F:15])([CH2:12][CH2:13]I)[O:4]1.[OH-].[K+]>>[F:19][C:16]([F:17])([F:18])[C:3]1([C:2]([F:1])([F:20])[F:21])[O:4][C:5]([F:15])([CH:12]=[CH2:13])[C:6]([F:11])([CH:8]=[CH2:9])[O:7]1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 15686468HCID 15686468, compound

Product 1

HCID 11022884HCID 11022884, compoundYield 49.3%

Procedure

In a flask was charged above compound 9 (95 g, 0.17 mole), 10 M KOH (189 ml, 1.89 mole) and phase transfer catalyst (Note) (24.6 g as 60% w/w aqueous solution, 0.034 mole). The reaction mixture was vigorously stirred at ambient temperature for 4 hrs. The bottom organic layer was separated and was further purified by distillation giving 25.0 g (49.3% yield) of the desired product was obtained as a clear, colorless liquid, bp. 90° C./200 mm.

Workup

  1. customThe bottom organic layer was separated
  2. distillationwas further purified by distillation

Sources & evidence

ORD record
ord-b215e8e969934f0faa5f0d34d9a2366c
Source dataset
uspto-grants-1993_10
Patent number
US05250709

Reaction notes

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