Boc-Leu-Ala-OBzl → H-Leu-Ala-OBzl

HRID 1655681노트

반응식

HRID 1655681 반응식
[NH:1]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C@H:2]([C:7]([NH:9][C@H:10]([C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])[CH3:11])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]>FC(F)(F)C(O)=O>[NH:1]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C@H:2]([C:7]([NH:9][C@H:10]([C:12]([O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:13])[CH3:11])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:12]([O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:13])[CH3:11])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6]

참가 물질

4

반응물 1

HCID 58901353Boc-Leu-Ala-OBzl

생성물 2

HCID 16742166H-Leu-Ala-OBzlHCID 58901353Boc-Leu-Ala-OBzl

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

Boc-Leu-Ala-OBzl was prepared by the procedure for dipeptide synthesis in Example 2. Boc-Leu-Ala-OBzl (23.7 g, 57.7 mmoles) was dissolved in 40 mL of anhydrous trifluoroacetic acid. After 15 min, excess trifluoroacetic acid was removed by evaporation and the residue was treated with ether to yield H-Leu-Ala-OBzl.trifluoroacetic acid as a crystalline product (22.8 g).

후처리

  1. customexcess trifluoroacetic acid was removed by evaporation
  2. additionthe residue was treated with ether

출처 및 근거

ORD 기록
ord-be20118ceac54b24ae301833c88df15f
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05250720

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