HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzimidazole → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Reactant | 1-Aminotetralin, (S)- | HCID 7058074 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1H-benzo[d]imidazol-2-amine | HCID 11623093 | — |
Reaction Steps
The title compound was prepared from 2-chlorobenzimidazole and (S)-1,2,3,4-tetrahydro-1-naphthylamine by Procedure A (reflux in toluene for 2 days). The product was purified by preparative LCMS, added HCl and isolated as a HCl salt (white solid, mp 257-258° C.). MS(ES+) m/z 264 ([M+1]+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737167B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e63c02bb260d484daeeb7469e673adba |
| Source note | uspto-grants-2010_06 |