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HRID16557

反应详情

EQUATION

反应方程式

HRID 16557 的结构方程式

REACTANTS

反应物

2
结构：Clc1nc2ccccc2[nH]1
HCID78572

1H-Benzimidazole, 2-chloro-

C7H5ClN2

结构：N[C@H]1CCCc2ccccc21
HCID7058074

(+)-1,2,3,4-Tetrahydro-1-naphthylamine

C10H13N

PRODUCTS

生成物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：c1ccc2c(c1)CCC[C@@H]2Nc1nc2ccccc2[nH]1
HCID11623093

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

The title compound was prepared from 2-chlorobenzimidazole and (S)-1,2,3,4-tetrahydro-1-naphthylamine by Procedure A (reflux in toluene for 2 days). The product was purified by preparative LCMS, added HCl and isolated as a HCl salt (white solid, mp 257-258° C.). MS(ES+) m/z 264 ([M+1]+, 100).

WORKUP

后处理

  1. customThe product was purified by preparative LCMS
  2. additionadded HCl