2-Propanol, sodium salt (1:1) → HCID 14801215, compound

HRID 1655805Notes

Reaction equation

HRID 1655805 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[C:7]([Cl:12])[C:6]=1[CH2:13]Br)(=[O:4])=[O:3].[CH3:15][CH:16]([CH3:18])[O-:17].[Na+]>C(O)(C)C>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[C:7]([Cl:12])[C:6]=1[CH2:13][O:17][CH:16]([CH3:18])[CH3:15])(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 109204432-Propanol, sodium salt (1:1)HCID 14801181HCID 14801181, compound

Product 1

HCID 14801215HCID 14801215, compoundYield 315.7%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

To a suspension comprising 20.0 g of 4-bromo-2-bromomethyl-3-chlorophenyl methyl sulfone and 200 ml of isopropanol, 100 ml of an isopropanol solution of sodium isopropoxide (prepared from 1.4 g of metal sodium) was added at room temperature, and the mixture was stirred overnight. The post treatment was conducted in the same manner as in Example 1-3-(2) to obtain 18.4 g of the desired product.

Workup

  1. additionwas added at room temperature

Sources & evidence

ORD record
ord-0256e3ec5c044ea49706849cb8a84379
Source dataset
uspto-grants-1993_10
Patent number
USRE034408

Reaction notes

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