4-Hydroxybenzoic Acid → HCID 54140554, compound

HRID 1655815Notes

Reaction equation

HRID 1655815 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][CH:12]([O:15][CH2:16][CH2:17][CH3:18])[CH2:13]O.S(=O)(=O)(O)O>C1C=CC=CC=1>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:11][CH:12]([CH3:13])[O:15][CH2:16][CH2:17][CH3:18])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 1354-Hydroxybenzoic AcidHCID 1118Sulfuric AcidHCID 250552-Propoxypropan-1-ol

Product 1

HCID 54140554HCID 54140554, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3.2 g of p-hydroxybenzoic acid and 13.8 g of optically active 2-methyl-2-propyloxyethanol were refluxed under heating together with 1 ml of sulfuric acid in benzene for 20 hours. The reaction liquid was condensed and purified by column chromatography to obtain 5.0 g (yield: 90 %) of the product.

Workup

  1. customThe reaction liquid
  2. customcondensed
  3. custompurified by column chromatography

Sources & evidence

ORD record
ord-645967e3bc8a4d978d94843e6b132937
Source dataset
uspto-grants-1993_10
Patent number
US05252251

Reaction notes

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