反应详情

温度

25 °C

2-Acetamido-2,3-dimethylbutyric acid (16 g) is dissolved in THF (200 mL) and dicyclohexylcarbodiimide (DCC, 21.0 g) is added. The mixture is allowed to stir for 16 hours at 25° C. At the end of this time the mixture is filtered and evaporated to dryness. The residue is dissolved in CH2Cl2 (10 mL) and filtered again. Evaporation of the filtrate gives the crude product which is purified by distillation at 0.65 mmHg, having bp 50° C.

1. filtrationAt the end of this time the mixture is filtered
2. customevaporated to dryness
3. dissolutionThe residue is dissolved in CH2Cl2 (10 mL)
4. filtrationfiltered again
5. customEvaporation of the filtrate