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HRID1655887

反应详情

EQUATION

反应方程式

HRID 1655887 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COC(=O)c1ccccc1S(N)(=O)=O
HCID42546

2-(Methoxycarbonyl)benzenesulfonamide

C8H9NO4S

结构：Cc1cc(C(=O)Cl)nn1C
HCID2776364

1,5-Dimethyl-1H-Pyrazole-3-Carbonyl Chloride

C6H7ClN2O

PRODUCTS

生成物

1
结构：COC(=O)c1ccccc1S(=O)(=O)NC(=O)c1cc(C)n(C)n1
HCID19789275

未命名化合物

收率 68.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

10.8 g of 2-methoxycarbonylphenylsulfonamide, 8.6 g of 1,5-dimethylpyrazole-3-carbonyl chloride and 13.8 g of potassium carbonate in 200 ml of absolute acetone are refluxed for 8 h. The solvent is removed by distillation and then the residue is taken up in water and the pH is adjusted to 2. The precipitate is filtered off with suction and washed with H2O until neutral. The residue is stirred with ether, filtered off with suction and dried under reduced pressure. 11.6 g of N-(2-methoxycarbonylphenylsulfonyl)-1,5-dimethylpyrazole-3-carboxamide with a melting point of 176°-177° C. are obtained (active ingredient Example No. 40).

WORKUP

后处理

  1. customThe solvent is removed by distillation
  2. filtrationThe precipitate is filtered off with suction
  3. washwashed with H2O until neutral
  4. filtrationfiltered off with suction
  5. customdried under reduced pressure