1-(1-Benzyl-1H-imidazol-2-yl)methanamine → HCID 136098640, compound

HRID 1655944Notes

Reaction equation

HRID 1655944 reaction equation
[CH3:1][C:2]1[NH:11][C:10](=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:13][N:14]([C:17]3[CH:27]=[CH:26][C:20]([C:21]([N:23]=[N+]=[N-])=[O:22])=[CH:19][CH:18]=3)[CH2:15][CH3:16])[CH:8]=2)[N:3]=1.[CH2:28]([N:35]1[CH:39]=[CH:38][N:37]=[C:36]1[CH2:40]N)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH2:28]([N:35]1[CH:39]=[CH:38][N:37]=[C:36]1[CH2:40][NH:23][C:21](=[O:22])[C:20]1[CH:26]=[CH:27][C:17]([N:14]([CH2:13][C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[N:3]=[C:2]([CH3:1])[NH:11][C:10]3=[O:12])[CH2:15][CH3:16])=[CH:18][CH:19]=1)[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 134780111-(1-Benzyl-1H-imidazol-2-yl)methanamineHCID 136403346HCID 136403346, compound

Product 1

HCID 136098640HCID 136098640, compoundYield 21%

Procedure

Using the process described in Example 5, p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-ethylamino]benzoyl azide was reacted with (1-benzylimidazol-2-yl)methylamine to give N-(1-benzylimidazol-2-yl)methyl-p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-ethylamino]benzamide (containing 1.3 equivalents of water) in 21% yield, m.p. 217°-221° C.

Sources & evidence

ORD record
ord-97ca514854c0493e9214cdb0b9a4c722
Source dataset
uspto-grants-1993_10
Patent number
US05252573

Reaction notes

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