Ammonium Hydroxide → HCID 15079241, compound

HRID 1655945Notes

Reaction equation

HRID 1655945 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([C:13](OCC)=[O:14])[N:10]=[C:9]1[CH2:18][OH:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[NH4+:21]>C(O)C>[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]([NH2:21])=[O:14])[N:10]=[C:9]1[CH2:18][OH:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 15079239HCID 15079239, compound

Product 1

HCID 15079241HCID 15079241, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of ethyl 1-benzyl-2-hydroxymethylimidazole-4-carboxylate (described immediately above, 1 g), an aqueous ammonium hydroxide solution (specific gravity 0.88 g/ml, 60 ml) and ethanol (25 ml) was stirred at laboratory temperature for 48 hours and then heated to 50° C. for 4 hours. The mixture was evaporated to give 1-benzyl-2-hydroxymethylimidazole-4-carboxamide, m.p. 204°-207° C.

Workup

  1. customThe mixture was evaporated

Sources & evidence

ORD record
ord-fe46487055ac48d99344e205c0e280de
Source dataset
uspto-grants-1993_10
Patent number
US05252573

Reaction notes

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