反应详情

Quinoline-2,3-dicarboxylic acid (1.29 g) and urea (709 mg) were ground together and heated at 170° for 3 h. The cooled mass was treated with water (50 mL) and triturated. The resulting solid was filtered, washed with water, and air dried to give the title compound as a white solid (450 mg). M.p.>300°.

1. temperatureheated at 170° for 3 h
2. customtriturated
3. filtrationThe resulting solid was filtered
4. washwashed with water, and air
5. customdried