HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 13883242, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| Reactant | Diethyloxalacetate sodium | HCID 23179480 | — |
| Product | HCID 13883242 | HCID 13883242 | — |
Reaction Steps
A suspension of 2-aminopyridine-3-carboxaldehyde (8.67 g) in absolute ethanol (500 mL) was treated with piperidine (1.7 mL) and sodium diethyloxalacetate (29.84 g) and heated to reflux for 18 h. The solvent was evaporated and the residue purified by chromatography on silica using 70% ethyl acetate-hexane as eluent to afford the title compound (2.6 g). M.p. 83°-85°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05252560 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-2cf11ea19e0d429384c1738730d51a55 |
| Source note | uspto-grants-1993_10 |