反应详情

A suspension of 2-aminopyridine-3-carboxaldehyde (8.67 g) in absolute ethanol (500 mL) was treated with piperidine (1.7 mL) and sodium diethyloxalacetate (29.84 g) and heated to reflux for 18 h. The solvent was evaporated and the residue purified by chromatography on silica using 70% ethyl acetate-hexane as eluent to afford the title compound (2.6 g). M.p. 83°-85°.

1. temperatureheated
2. temperatureto reflux for 18 h
3. customThe solvent was evaporated
4. customthe residue purified by chromatography on silica using 70% ethyl acetate-hexane as eluent