反应详情

温度

5 °C

Dissolve 1,2,3,4-tetrahydro-2-naphthoic acid (10 g, 57 mmol) in methanol (100 mL) and add dimethoxypropane (3 mL). Cool to 5° C. and saturate with hydrogen chloride gas. Allow to stand overnight then evaporate the solvent in vacuo. Take the residue up in ethyl ether, wash with saturated sodium hydrogen carbonate and dry (MgSO4). Evaporate the solvent in vacuo and distill to give 2-carbomethoxy-1,2,3,4-tetrahydronaphthalene; bp 90°-96° C.@0.25 mm Hg).

1. concentrationsaturate with hydrogen chloride gas
2. customthen evaporate the solvent in vacuo
3. washwash with saturated sodium hydrogen carbonate
4. dry with materialdry (MgSO4)
5. customEvaporate the solvent in vacuo
6. distillationdistill