2-Butanone, 3-bromo- → HCID 19787526, compound

HRID 1656295Notes

Reaction equation

HRID 1656295 reaction equation
[C:1]([NH:4][C:5]1[CH:6]=[C:7]([CH:9]=[C:10]([CH3:12])[CH:11]=1)[NH2:8])(=[O:3])[CH3:2].Br[CH:14]([CH3:18])[C:15](=O)[CH3:16]>CN(C)C=O>[C:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:9]([C:14]([CH3:18])=[C:15]([CH3:16])[NH:8]2)=[C:10]([CH3:12])[CH:11]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 131422-Butanone, 3-bromo-HCID 19787527HCID 19787527, compound

Product 1

HCID 19787526HCID 19787526, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

9 g of 3-acetamido-5-methylaniline are dissolved in 20 ml of dimethylformamide and 3.2 ml of 3-bromobutan-2-one are then added. The mixture is left at ambient temperature for 1 hour and the temperature is then raised to 100°-110° C. for one hour. The mixture is cooled and poured into 100 ml of ice-water. The precipitate is drained and washed successively with 50 ml of distilled water, 20 ml of ethanol and 20 ml of isopropyl ether. 4.2 g of white precipitate are obtained.

Workup

  1. temperaturethe temperature is then raised to 100°-110° C. for one hour
  2. temperatureThe mixture is cooled
  3. washwashed successively with 50 ml of distilled water, 20 ml of ethanol and 20 ml of isopropyl ether

Sources & evidence

ORD record
ord-946d25eb59e14301b062b0240541b520
Source dataset
uspto-grants-1993_10
Patent number
US05254135

Reaction notes

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