HCID 19787526, compound → HCID 18459474, compound

HRID 1656296Notes

Reaction equation

HRID 1656296 reaction equation
C([NH:4][C:5]1[CH:13]=[C:12]2[C:8]([C:9]([CH3:15])=[C:10]([CH3:14])[NH:11]2)=[C:7]([CH3:16])[CH:6]=1)(=O)C>Cl>[NH2:4][C:5]1[CH:13]=[C:12]2[C:8]([C:9]([CH3:15])=[C:10]([CH3:14])[NH:11]2)=[C:7]([CH3:16])[CH:6]=1

Participants

3

Reactant 1

HCID 19787526HCID 19787526, compound

Product 1

HCID 18459474HCID 18459474, compoundYield 118.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of 3.67 g of 6-acetamido-2,3,4-trimethylindole in 15 ml of hydrochloric acid (12N) is brought to 100° C. for 3 hours. The mixture is cooled and the precipitate is drained and washed successively with 3 ml of hydrochloric acid (12N) and 20 ml of absolute ethanol. 3.5 g of a white precipitate are obtained.

Workup

  1. temperatureThe mixture is cooled
  2. washwashed successively with 3 ml of hydrochloric acid (12N) and 20 ml of absolute ethanol

Sources & evidence

ORD record
ord-d61ec39ac7654e539aa0557f737eebab
Source dataset
uspto-grants-1993_10
Patent number
US05254135

Reaction notes

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