1-(3-Chlorophenyl)piperazine → HCID 19787740, compound

HRID 1656330Notes

Reaction equation

HRID 1656330 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:4][C:3]=1[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[Cl:21][C:22]1[CH:23]=[C:24]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:25]=[CH:26][CH:27]=1>C(O)CCC>[C:8]1([C:5]2[N:6]=[N:7][C:2]([N:31]3[CH2:30][CH2:29][N:28]([C:24]4[CH:25]=[CH:26][CH:27]=[C:22]([Cl:21])[CH:23]=4)[CH2:33][CH2:32]3)=[C:3]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:4]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 19787778HCID 19787778, compound

Product 1

HCID 19787740HCID 19787740, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
120 °C

Procedure

Suspend 2 mmol (570 mg) of 6-chloro-5-benzyl-3-phenyl-1,2,4-triazine obtained in Step A of Example 57 in 40 ml of butanol, and add 4 equivalents of 1-(3-chlorophenyl)piperazine. Heat for 12 hours at 120° C., concentrate the solution, take up in ether, filter the resulting precipitate and recrystallise it from ethanol.

Workup

  1. concentrationconcentrate the solution
  2. filtrationfilter the resulting precipitate
  3. customrecrystallise it from ethanol

Sources & evidence

ORD record
ord-33c3503bd86b4e54900d75e5ca4bc981
Source dataset
uspto-grants-1993_10
Patent number
US05254548

Reaction notes

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