Potassium Carbonate → HCID 19787950, compound

HRID 1656342Notes

Reaction equation

HRID 1656342 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([NH2:10])=[O:9])[CH:5]=[CH:4][N:3]=1.[O:11]1[C:15]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[O:11]1[C:15]2([CH2:20][CH2:19][N:18]([C:2]3[N:7]=[C:6]([C:8]([NH2:10])=[O:9])[CH:5]=[CH:4][N:3]=3)[CH2:17][CH2:16]2)[O:14][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 2470282-Chloropyrimidine-4-carboxamide

Product 1

HCID 19787950HCID 19787950, compoundYield 97.6%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

5 g (0.0318 mol) of 2-chloropyrimidine-4-carboxamide, 4.55 g (0.0318 mol) of 1,4-dioxa-8-azaspiro[4.5]decane and 6.6 g (0.0477 mol) of potassium carbonate are introduced into 100 ml of 2-butanone. The mixture is heated and stirred at reflux temperature for 6 hours. The mixture is filtered and the filtrate is concentrated under reduced pressure. 8.2 g of product are obtained which are recrystallised from 2-propanol. 4.1 g of product are obtained.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux temperature for 6 hours
  3. filtrationThe mixture is filtered
  4. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-09fb81aaa4de4eb29dfdeb639fd48be5
Source dataset
uspto-grants-1993_10
Patent number
US05254560

Reaction notes

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