Dichloromethane → (4-aminopiperidin-1-yl)-[2-(6-tert-butyl-4-ethoxy-3-pyridinyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]methanone

HRID 165636Notes

Reaction equation

HRID 165636 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:15])[N:16]2[C:17]([c:37]3[cH:38][n:39][c:40]([C:46]([CH3:47])([CH3:48])[CH3:49])[cH:41][c:42]3[O:43][CH2:44][CH3:45])=[N:18][C:19]([CH3:29])([c:30]3[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]3)[C:20]2([CH3:21])[c:22]2[cH:23][cH:24][c:25]([Cl:28])[cH:26][cH:27]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:50].[Cl:58][CH2:59][Cl:60].[OH:51][C:52]([C:53]([F:54])([F:55])[F:56])=[O:57]>>[NH2:7][CH:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:15])[N:16]2[C:17]([c:37]3[cH:38][n:39][c:40]([C:46]([CH3:47])([CH3:48])[CH3:49])[cH:41][c:42]3[O:43][CH2:44][CH3:45])=[N:18][C:19]([CH3:29])([c:30]3[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]3)[C:20]2([CH3:21])[c:22]2[cH:23][cH:24][c:25]([Cl:28])[cH:26][cH:27]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 76588629tert-butyl N-[1-[2-(6-tert-butyl-4-ethoxy-3-pyridinyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazole-1-carbonyl]piperidin-4-yl]carbamate

Product 1

HCID 178466405(4-aminopiperidin-1-yl)-[2-(6-tert-butyl-4-ethoxy-3-pyridinyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]methanone

Sources & evidence

ORD record
ord-720f6f8754c84ef199769739f5fe2af0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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