Potassium Carbonate → HCID 19788015, compound

HRID 1656362Notes

Reaction equation

HRID 1656362 reaction equation
[N:1]1([CH2:6][CH:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH3:18])([CH3:17])[CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[F:25][C:26]([F:38])([F:37])[C:27]1[CH:32]=[CH:31][C:30]([CH2:33][C:34](Cl)=[O:35])=[CH:29][CH:28]=1>C(Cl)(Cl)Cl>[N:1]1([CH2:6][C:7]2([C:34](=[O:35])[CH2:33][C:30]3[CH:29]=[CH:28][C:27]([C:26]([F:37])([F:25])[F:38])=[CH:32][CH:31]=3)[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH3:18])([CH3:17])[CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 148109432-(4-(Trifluoromethyl)phenyl)acetyl chlorideHCID 15005454HCID 15005454, compound

Product 1

HCID 19788015HCID 19788015, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared as Ex. No. 1, from 2.44 g (10.0 mmoles) of 1-(pyrrolidin-1-yl)methyl-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline, 3.04 g (22.0 mmoles) of anhydrous potassium carbonate and 2.45 g (11.01 mmoles) of 4-trifluoromethylphenylacetyl chloride in 40 ml of dry chloroform.

Workup

  1. customPrepared as Ex

Sources & evidence

ORD record
ord-27e1921eae794ece9ae49f541854793d
Source dataset
uspto-grants-1993_10
Patent number
US05254564

Reaction notes

Loading…