反应详情

In a 5 liter flask were combined 507 g (2.09 mole) of methyl-3-bromomethyl-5-methylbenzoate with 615 g (6.3 mole) of potassium acetate in 2850 ml of glacial acetic acid and refluxed for 3 hours. The contents of the flask were then cooled down to room temperature and divided in 3 equal portions for work up. Each portion was poured into 2 liter of water and extracted with ethyl ether (3×300 ml). The combined organic layers were washed with water (3×600 ml) and then with 2% aqueous sodium hydroxide (5×200 ml) and then dried over sodium sulfate. The solvent was then eliminated in the rotavap to give 420.8 g (90% yield) of crude product, used as such in the next step.

1. customIn a 5 liter flask were combined
2. extractionextracted with ethyl ether (3×300 ml)
3. washThe combined organic layers were washed with water (3×600 ml)
4. dry with materialwith 2% aqueous sodium hydroxide (5×200 ml) and then dried over sodium sulfate