Dimethyl Sulfoxide → 3-Formyl-5-methylbenzoic acid

Temperature

-78 °C

In a 1 liter 4-necked round-bottomed flask were placed 500 ml of methylene chloride and cooled down to -78° C. 41.3 g (0.33 mole) of oxalyl chloride were added slowly, followed by dropwise addition of 56.4 g (0.72 mole) of dry dimethylsulfoxide in 30 ml of methylene chloride, all the while keeping the temperature below -70° C. After the addition was completed the reaction mixture was stirred at -78° C. for 30 minutes and 60 g (0.36 mole) of the previously prepared 3-hydroxymethyl-5-methylbenzoic acid were added in 1 portion, followed by dropwise addition of 131.4 g (1.3 mole) of triethylamine, keeping the temperature below -65° C. during each of the additions. The reaction mixture was then warmed up slowly to room temperature, stirred for 90 minutes and then washed with 2% aqueous sodium hydroxide (3×500 ml). The combined basic layers were washed with hexane once and acidified with concentrated hydrochloric acid and then extracted with ethyl acetate (4×500 ml). The combined organic layers were washed with water (1×500 ml) and then with brine (1×300 ml) and dried over anhydrous magnesium sulfate. The solvent was then eliminated in a rotavap. The resulting oily product was triturated with hexane and filtered yielding 52 g (88%) 3-formyl-5-methylbenzoic acid as a tan solid.

1. customIn a 1 liter 4-necked round-bottomed flask were placed
2. customthe temperature below -70° C
3. additionAfter the addition
4. customthe temperature below -65° C.
5. temperatureThe reaction mixture was then warmed up slowly to room temperature
6. stirringstirred for 90 minutes
7. washwashed with 2% aqueous sodium hydroxide (3×500 ml)
8. washThe combined basic layers were washed with hexane once
9. extractionextracted with ethyl acetate (4×500 ml)
10. washThe combined organic layers were washed with water (1×500 ml)
11. dry with materialwith brine (1×300 ml) and dried over anhydrous magnesium sulfate
12. customThe solvent was then eliminated in a rotavap
13. customThe resulting oily product was triturated with hexane
14. filtrationfiltered

ORD record

ord-9eaef582196f48acae201ed790fda9b8

Source dataset

uspto-grants-1993_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05254584