3-Cyanopyridine → HCID 12218258, compound

HRID 1656528Notes

Reaction equation

HRID 1656528 reaction equation
[CH2:1]([OH:3])[CH3:2].C([Cl:7])(=O)C.[C:8]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)#[N:9]>C(Cl)(Cl)Cl>[ClH:7].[N:12]1[CH:13]=[CH:14][CH:15]=[C:10]([C:8](=[NH:9])[O:3][CH2:1][CH3:2])[CH:11]=1

Participants

5

Reactant 3

HCID 793-CyanopyridineHCID 702EthanolHCID 6367Acetyl chloride

Product 1

HCID 12218258HCID 12218258, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Conditions

Temperature
25 °C

Procedure

To a solution of ethanol (200 mL) in chloroform (100 mL) at 0° C. was added acetyl chloride (190 mL) and a solution of 3-cyanopyridine (25 g) in (300 mL) of chloroform. The solution was allowed to warm to 25° C. and to stand for 1 day. A white solid separated from solution. The solvent was removed and the white solid collected and washed with ether to provide pure ethyl 3-pyridine-carboximidate hydrochloride as a white solid; MS: m/z=152(M+1).

Workup

  1. customA white solid separated from solution
  2. customThe solvent was removed
  3. customthe white solid collected
  4. washwashed with ether

Sources & evidence

ORD record
ord-9fcab7f633dd440583043d9d6e848785
Source dataset
uspto-grants-1993_10
Patent number
US05254558

Reaction notes

Loading…