Methanol → HCID 10381261, compound

HRID 1656530Notes

Reaction equation

HRID 1656530 reaction equation
CO[CH:3]=[C:4]([C:9]([O:11]C)=O)[C:5]([O:7][CH3:8])=[O:6].[CH3:13][O:14][CH:15]([O:26][CH3:27])[CH2:16][NH:17][C:18]([C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)=[NH:19].CO>C(OCC)C>[CH3:27][O:26][CH:15]([O:14][CH3:13])[CH2:16][N:17]1[C:9](=[O:11])[C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][N:19]=[C:18]1[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 90770Dimethyl methoxymethylenemalonateHCID 178495959HCID 178495959, compound

Product 1

HCID 10381261HCID 10381261, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Dimethyl methoxymethylenemalonate and N-(2,2-dimethoxy-ethyl) -3-pyridinecarboxamidine were subjected to a procedure similar to that described in Example 1.b. Chromatography, with methanol:diethyl ether (gradient, 0:100, 10:90) as the eluent, gave methyl 1-(2,2-dimethoxy-ethyl)-2-(3-pyridyl)pyrimidin-6(1H)-one-5-carboxylate as an oil; MS: m/z=320(M+1); TLC: Rf =0.4, methanol:diethyl ether (5:95).

Sources & evidence

ORD record
ord-f7d9fc97ff084dbb84915e2c0d6500d3
Source dataset
uspto-grants-1993_10
Patent number
US05254558

Reaction notes

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