Methanol → HCID 19787880, compound

HRID 1656532Notes

Reaction equation

HRID 1656532 reaction equation
C(OC([NH:11][C:12]1[C:17](=[O:18])[N:16]([CH2:19][C:20]([NH:22][CH:23]([CH:30]([CH3:32])[CH3:31])[C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])=[O:21])[C:15]([C:33]2[CH:38]=[CH:37][C:36]([N+:39]([O-])=O)=[CH:35][CH:34]=2)=[N:14][CH:13]=1)=O)C1C=CC=CC=1.CO>ClCCl>[NH2:11][C:12]1[C:17](=[O:18])[N:16]([CH2:19][C:20]([NH:22][CH:23]([CH:30]([CH3:32])[CH3:31])[C:24](=[O:29])[C:25]([F:26])([F:28])[F:27])=[O:21])[C:15]([C:33]2[CH:34]=[CH:35][C:36]([NH2:39])=[CH:37][CH:38]=2)=[N:14][CH:13]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 10415744HCID 10415744, compound

Product 1

HCID 19787880HCID 19787880, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-[5-Benzyloxycarbonylamino-2-(4-nitrophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide was subjected to a procedure similar to that described in Example 6 to give a brown solid; chromatography solvent: methanol:dichloromethane (gradient, 5:95, 10:90); NMR (DMSO/D2O): 7.29 (s,1), 7.01 (d,2), 6.49 (d,2), 4.52 (m,2), 4.10 (d,2), 2.25 (m,1), 0.88 (d,3), 0.80 (d,3).

Workup

  1. customto give a brown solid

Sources & evidence

ORD record
ord-37d38ea397ef41d3b501ce755adeaa66
Source dataset
uspto-grants-1993_10
Patent number
US05254558

Reaction notes

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