HCID 14750961, compound → 2-Aminotetralin

HRID 1656618Notes

Reaction equation

HRID 1656618 reaction equation
Cl.[CH2:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[NH:12]CC(O)COC1C=CC=C2C=1C=C(CC)N2>C(O)C>[NH2:12][CH:3]1[CH2:4][CH2:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:2]1

Participants

3

Reactant 1

HCID 14750961HCID 14750961, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure described in Example 27, but starting from 2-ethyl-4-(2,3-epoxypropoxy)indole (10 g), obtained from 2-ethyl-4-hydroxyindole and epichlorohydrin according to the method described in Swiss Patent 527,188, and 2-aminotetralin (7.95 g) in ethanol (90 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-ethylindol-4-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 17 wherein Z is ethyl, and the chain is attached to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-95a95d1aecbe473f9ba7d0d931de8ae2
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

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