HCID 14750961, compound → 2-Aminotetralin

Participants

Reaction Steps

Following the procedure described in Example 27, but starting from 2-ethyl-4-(2,3-epoxypropoxy)indole (10 g), obtained from 2-ethyl-4-hydroxyindole and epichlorohydrin according to the method described in Swiss Patent 527,188, and 2-aminotetralin (7.95 g) in ethanol (90 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-ethylindol-4-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 17 wherein Z is ethyl, and the chain is attached to position 2 of the tetralin moiety).

Provenance & Evidence