HCID 14750969, compound → 2-Aminotetralin

HRID 1656620Notes

Reaction equation

HRID 1656620 reaction equation
Cl.[CH2:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[NH:12]CC(O)COC1C2OC(C(=O)C)=CC=2C=CC=1>C(O)C>[NH2:12][CH:3]1[CH2:4][CH2:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:2]1

Participants

3

Reactant 1

HCID 14750969HCID 14750969, compound

Product 1

HCID 346772-Aminotetralin

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure described in Example 27, but starting from 2-acetyl-7-(2,3-epoxypropoxy)benzofuran (23.2 g), obtained from 2-acetyl-7- hydroxybenzofuran and epichlorohydrin according to the teaching of Belgian Patent 783,440, and 2-aminotetralin (14.81 g) in ethanol (120 ml), N-(1,2,3,4-tetrahydronaphth-2-yl)-2-hydroxy-3-(2-acetylbenzofuran-7-yloxy)propanamine hydrochloride is obtained ((i): R=H, Ar=radical 24 wherein Z is acetyl and the chain bridges position 4 of the Ar group to position 2 of the tetralin moiety).

Sources & evidence

ORD record
ord-61c2807c31da4ba2bb05535ac595561c
Source dataset
uspto-grants-1993_10
Patent number
US05254595

Reaction notes

Loading…